ABSTRACT
Purpose: The purpose of our report is to present two patients with acute peripheral arterial thrombosis as a result of COVID-19 infection and discuss the unique features of arterial thrombosis in patients suffering from COVID-19. Case Report: We present a 66-year-old female and a 53-year-old male with proven COVID-19 infection who developed acute lower limb ischemia. Common features in both patients were a multi-segment arterial occlusion in previously healthy arteries, developing despite prophylactic anticoagulation about 15 days after the onset of COVID-19 symptoms. Limb salvage was achieved by early diagnosis and expedited thrombectomy. Conclusion: COVID-19 associated arterial thromboembolism has several unique features reflecting the underlying pathogenetic mechanism which involves a combination of coagulopathy and endothelial dysfunction. Clinical vigilance allowing early diagnosis and expedited surgery remains the key to a successful outcome.